ETV6/RUNX1 FUSION GENE ABROGATION DECREASES THE ONCOGENICITY OF TUMOUR CELLS IN A PRECLINICAL MODEL OF ACUTE LYMPHOBLASTIC LEUKAEMIA

ETV6/RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia

Background: The t(12;21)(p13;q22), which fuses ETV6 and RUNX1 genes, is the most common genetic abnormality in children with B-cell precursor acute lymphoblastic leukaemia.The implication of the fusion protein in leukemogenesis seems to be clear.However, its role in the maintenance of the disease continues to be controversial.Methods: Generation of

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Advances in High Throughput Proteomics Profiling in Establishing Potential Biomarkers for Gastrointestinal Cancer

Gastrointestinal cancers (GICs) remain the most diagnosed cancers and accounted for the mcintosh men220 for sale highest cancer-related death globally.The prognosis and treatment outcomes of many GICs are poor because most of the cases are diagnosed in advanced metastatic stages.This is primarily attributed to the deficiency of effective and reliab

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